This thesis aims to highlight the benefits and drawbacks of the adoption of liquid hydrogen in hypersonic vehicle concepts. A brief overview of the technological challenges and solutions, environmental and economic aspects, is performed, including considerations on the aircraft and airport design, safety and handling. The analysis identifies and discusses multidisciplinary issues related to the development of a liquid hydrogen system that allows adequate levels of integration on the aircraft and a full infrastructure to support it. It also includes the means for delivery and storage as well as requirements, regulations and standards. Key factors that play an important role in pointing out the potential of liquid hydrogen and its impact on aviation are emphasized.