In the medtech industry models of the cardiiovascular systems and simulations are valuable tools for the development of new products ad therapies. The simulator Aplysia has been developed over several decade and is able to replicate a wide range of phenomena involved in the physiology and pathophysiology of breathing and circulation. Aplysia is also able to simulate the hemodynamics phenomena starting from a set of patient model parameters enhancing the idea of a "digital twin", i.e. a patient-specific representative simulation. Having a good starting estimate of the patient model parameters is a crucial aspect to start the simulation. A firstestimate can be given by looking at patient monitoring data but medical expertise is required.