Optical devices based on Quantum Dot (QD) structures have gained growing attention in recent years due to the expected superior properties with respect to their bulk counterparts, thus increasing the need for efficient modeling tools to analyze and predict their performances. Mode locked QD lasers are a common example of devices relying on zero-dimensional confinement with a large number of applications, ranging from the biomedical world to communication systems, with pulse repetition frequencies reaching tens or even hundreds of gigahertz. They can also be employed in the realization of compact RF signal sources generating ultra-short optical pulses at high repetition rates, providing appealing features in terms of size, power consumption and bandwidth from a sub-terahertz transmission system perspective.