The use of Traditional Chinese Medicine spans thousands of years, yet its integration into modern pharmaceutical research has been limited. A major challenge is the lack of systematic evaluation of the chemical properties of TCM compounds, which slows their development into approved pharmaceuticals. Adopting drug-likeness as a metric, which refers to the physicochemical and structural properties of a molecule that make it potentially suitable for development as a pharmaceutical drug, is crucial for determining whether a compound could be a viable drug candidate. Given the diversity and complexity of TCM, manually evaluating each compound for drug-likeness is impractical. Therefore, an efficient, systematic approach is needed to assess the drug-likeness of TCM compounds and understand the chemical structures that contribute to their therapeutic potential.