The noise produced by HVAC systems, especially on work vehicles like off-road vehicles where workers spend long periods of time, can be very harmful to the end user. The purpose of this study is to validate a linear prediction method capable of assessing the subjective acoustic annoyance of HVAC noise, in order to avoid subjective tests and have a single equation that defines the average perception of the end user. The research follows a systematic methodology that includes literature review, parameters translation, signal acquisition tests, psychoacoustic parameter analysis, subjective evaluations, and the development of a sound quality prediction model. The literature review on the topic helped to ensure the most accurate possible basic methodology, with particular attention to the psychoacoustic parameters used, subjective rating scales, and prediction methodologies applied.