Stress losses in tendons of post-tensioned bridges not only significantly impact their structural performance but also pose risks to their serviceability state and overall integrity over time. These losses can lead to a reduction in structural capacity due to decreased prestress force, increased deflection under load, and the development of cracks compromising structural integrity. Furthermore, they contribute to a loss of structural redundancy and heightened vulnerability to dynamic loading effects such as fatigue and damage. This research aims to investigate the implications of such damage during both construction and operational lifespan of a post-tensioned bridge located in northern Italy, highlighting the crucial factors affecting its long-term performance and safety.