Multi-electrode array (MEA) chips are rapidly growing as one of the main technologies to unveil complex electrophysiological dynamics of both cells and tissues. Because of their high density and resolution, MEA devices are ideal candidates to record and stimulate single cells in culture. Nevertheless, packaging approaches that protect electronic components from harsh biological environments and allow for long-term device usage remain undressed. Further, the correct addressability of each individual electrode is a major importance to enable correlation between MEA measurements and microscopy. The first part of this thesis was focused on assessing long term stability of the devices and characterizing chip performance.