Spatially extended touch sensation
Georgi Hristov Spasov
Spatially extended touch sensation.
Rel. Andrea Pagnani. Politecnico di Torino, Corso di laurea magistrale in Physics Of Complex Systems (Fisica Dei Sistemi Complessi), 2020
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Abstract
Previous work ( Eastwood et al, PNAS ; Sanzeni et al, eLife; Satta et al., J. Gen Physiology, 2019) developed a new theoretical model for the coupled process by which loads applied to the skin of the worm are transduced through the tissue and TRNs are activated. The worm is modeled as a cylindrical shell under internal pressure, which is indented by a spherical ball, as in the experimental set-up. The transmission of mechanical stimuli through the tissue is obtained via simulations of nonlinear equations for elastic media. As for the gating of the neuron, the gating mechanism is supposed to be provided by tangential stimuli on MeT channels, which are read out as an increased probability of channel activation.
This differs from previous models for hair cell bundles, where the gating is perpendicular
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