Maria Luisa Lotito
Implantable 3D printed encapsulation system with localized immunomodulation for cell transplantation.
Rel. Danilo Demarchi. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2018
Abstract
Cell-based therapy is increasingly important in modern medicine for the treatment of various diseases including those related to the endocrine system, central nervous system, as well as cancer and cardiovascular disease. Among the treatment options for the aforementioned diseases is organ transplantation, however the number of donors is not sufficient for patients waiting to receive an organ. Moreover, these patients are required to take immunosuppressants for the rest of their lives to prevent rejection. Another possible solution may be hormonal replacement therapies, but even these treatments are not sufficient to restore the metabolic interactions of hormones. Cellular encapsulation systems are one of the leading strategies to recover the function of organs.
Stem cells, blood cells, and pancreatic islets are the most used cell types for this purpose
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