In the last decades, bioactive glasses have gained great importance in bone tissue engineering (BTE) applications due to their chemical similarity to the inorganic phase of bone and their excellent bioactivity. In fact, this class of biomaterials not only provides a biocompatible surface, but can also lead and enhance the deposition of new bone tissue. However, their relatively low mechanical properties, low resistance to fracture under loads and high brittleness limit their application in BTE approaches, which require robust mechanical structure and high resistance to applied stress. The aim of this work was the design and characterization of 45S5 Bioglass®-based scaffolds coated with tailor-made polymers.