The aim of the project is to work parallely on two very different techniques in order to improve the detection of a particular charged molecules. The first subject deals with SERS (Surface Enhanced Raman Spectroscopy) sensors. Exploiting the Raman effect it’s possible to create a fingerprint of specific molecules collecting the energy exchange after the irradiation with a monochromatic flux. This analysis makes possible the detection of particular molecules in heterogeneus analytes. The main drawback of the Raman technique is the poor sensitivity, making necessary to find enhancement ways. For this purpose it’s possible to exploit the high power of the localized surface plasmons.