Politecnico di Torino (logo)

ROS-scavenging magnetic nanocubes as a novel theranostic for brain cancer

Francesca Tomatis

ROS-scavenging magnetic nanocubes as a novel theranostic for brain cancer.

Rel. Gianni Ciofani, Christos Tapeinos. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2018

PDF (Tesi_di_laurea) - Tesi
Licenza: Creative Commons Attribution Non-commercial No Derivatives.

Download (11MB) | Preview

Smart drug delivery systems (SDDS) represent an innovative way to treat glioblastoma multiforme (GBM) by holding attractive characteristics like biomimicry, easiness in crossing the blood brain barrier (BBB) and multi-stimuli responsiveness, that enhance the therapeutic effectiveness and reduce the side-effects of the current treatment strategies. In this study, we hypothesized that the coating, with a GBM cell membrane, of a composite nanoparticle (NP) consisting of a magnetic core and an antioxidant shell (MANP), and its loading with the drug temozolomide (TMZ), could represent a novel system with an inherent targeting ability that can effectively treat GBM. These MANPs have also the potential to be used for guided delivery and as magnetic resonance imaging contrast agents.

Relators: Gianni Ciofani, Christos Tapeinos
Academic year: 2018/19
Publication type: Electronic
Number of Pages: 124
Corso di laurea: Corso di laurea magistrale in Ingegneria Biomedica
Classe di laurea: New organization > Master science > LM-21 - BIOMEDICAL ENGINEERING
Aziende collaboratrici: FONDAZIONE IIT
URI: http://webthesis.biblio.polito.it/id/eprint/8968
Modify record (reserved for operators) Modify record (reserved for operators)