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Hyaluronic acid gel for viscosupplementation

Giulia Fontanazza

Hyaluronic acid gel for viscosupplementation.

Rel. Roberta Maria Bongiovanni. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Dei Materiali, 2018


This thesis presents the project conducted with the French enterprise SYMATESE, located in the west of Lyon, specialized in biopolymers extraction and transformation for the development of medical devices. The objective of the project is to create a new product for the viscosupplementation characterized by the combination between the hyaluronic acid gel and an active substance. The final product should achieve some characteristics that are requested by the client: • defined pH; • defined buffer composition: no presence of phosphates; • osmolarity compatible with human body; • viscoelastic solid behavior of the gel (G’>G”) with a defined G’ value; • defined value of injection force; • maintenance of elastic properties and pH after accelerated ageing test. The project is innovative for the request of the pH and for the restriction about the phosphates: in fact, all the products for the viscosupplementation have neutral pH and many of them contain phosphates. This thesis is only a preliminary study that demonstrates the possibility of setting up a new type of viscosupplementation treatment that is not present in the global market.

Relators: Roberta Maria Bongiovanni
Academic year: 2018/19
Publication type: Electronic
Number of Pages: 83
Additional Information: Tesi secretata. Full text non presente
Corso di laurea: Corso di laurea magistrale in Ingegneria Dei Materiali
Classe di laurea: New organization > Master science > LM-53 - MATERIALS ENGINEERING
Ente in cotutela: Université Joseph Fourier Grenoble I (FRANCIA)
Aziende collaboratrici: UNSPECIFIED
URI: http://webthesis.biblio.polito.it/id/eprint/8330
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