Polymers are advanced materials found in almost every product of our daily life. To date, the importance of plastics has been highlighted as a result of their widespread use in different sectors of sciences, technologies and industry, from basic employments until medical and therapeutic applications. In the present scenario, because of their self-lubricating properties, polymers are extensively adopted for manufacturing sliding components (gears, bearings, cams, roller in conveyors, etc.) which undergo wear and tear. Along with their broad utilization for tribological purposes, the understanding of tribology of polymers is becoming increasingly relevant. This study is focused on a specific engineering thermoplastic material, the polyoxymethylene (POM).