Over the past decades, Extended Reality (XR), which refers to a spectrum of immersive technologies including Augmented Reality (AR), Mixed Reality (MR) and Virtual Reality (VR), has progressively gained ground in multiple fields such as entertainment, education, manufacturing and tourism. In particular, following the COVID-19 pandemic, XR technologies have been increasingly adopted in medical education to support procedural training, proving highly effective in improving clinical skills acquisition through safe and repeatable simulation environments. In this context, ultrasound-guided Internal Jugular Vein Cannulation represents a particularly challenging skill to master. It is a medical procedure in which a catheter is inserted into the internal jugular vein using real-time ultrasound imaging.