The rapid transition to renewable energy sources is a fundamental requirement to achieve carbon neutrality and decouple global economic growth from carbon emissions. Anion Exchange Membrane Water Electrolysis (AEMWE) is gaining traction because its non-noble transition metal catalysts significantly reduce capital costs. The objective of this thesis is the 3D thermo-mechanical modeling of a single-cell high-pressure AEM electrolyser to ensure performance efficiency at 30 bar. To achieve optimal operational aspects, cell layer material selection must be carefully evaluated regarding stability, economics, and mechanical performance. For each layer, most common materials have been assessed and based on different criteria such as performance, cost and availability in the commercial markets, different material configurations of the single cell have been suggested.