Coronary artery disease (CAD) is one of the leading causes of mortality worldwide. The progression of atherosclerotic plaques can lead to coronary stenosis, alter blood flow distribution, and impair myocardial perfusion. Consequently, understanding the hemodynamic mechanisms involved in the onset and progression of CAD remains a major focus of cardiovascular research. Over the last decades, computational fluid dynamics (CFD) has become a widely used tool for the investigation of coronary hemodynamics and the analysis of wall shear stress (WSS)-based metrics, which are recognized as relevant factors in atherosclerotic plaque progression and vulnerability. More recently, a topological approach based on the identification of WSS fixed points has been proposed, providing a description of the local flow organization near the vessel wall.