Thrombogenicity models for heart valve prostheses.Heart valve prostheses may promote thrombus formation through the interaction of device-related, anatomical, biological and hemodynamic factors. This thesis analyzes the mechanisms involved in the thrombogenicity of these devices, with attention to mathematical and computational approaches used to model post-implant thrombogenic risk. First, the biological bases of thrombogenesis are described. The interplay of platelet activation, coagulation, fibrin deposition, endothelial response, inflammation, and hemolysis giving rise to thrombus formation is presented. Additionally, the role of biomechanical factors in terms of wall shear stress magnitude, flow stagnation, oscillatory shear, residence time, and shear gradients is discussed. Second, device-specific thrombogenesis mechanisms are presented.