Sara Priscilla Mancosu
Hybrid functionalized nanoparticles for targeted microRNA delivery after myocardial infarction.
Rel. Valeria Chiono, Martina Coletto, Camilla Paoletti, Letizia Nicoletti. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2026
Abstract
This thesis investigate the design, functionalization and optimization of hybrid polymer-lipid nanoparticles for the targeted delivery of regenerative microRNA to the infarcted heart. By selectively targeting cardiomyocytes and cardiac fibroblasts, these nanoparticles aim to stimulate cardiac regeneration following myocardial infarction. This work was part of BIORECAR ERC project (contract nr: 772168, www.biorecar.polito.it) and POLIRNA ERC PoC project (contract nr: 101113522).
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