This work presents the development of a multidisciplinary and parametric framework for the conceptual design and optimization of pressurized lunar rovers, aimed at supporting future human surface exploration missions. The implementation of rover subsystems requires a rigorous, physics-based approach that takes into account key performance factors across multiple disciplines, while also allowing for the flexible exploration of alternative designs. The proposed framework enables the sizing and preliminary evaluation of rover architectures starting from the definition of mission requirements, including the structuring of the operational timeline and the analysis of subsystem activation during different mission phases. From these inputs, the framework performs an iterative analysis using analytical and semi-empirical models, organized in a modular structure to facilitate both model extensibility and fidelity refinement.