The exposure to chronic stress has been identified as a key risk factor underlying mental disorders, cognitive impairments, and complex pathologies. In this thesis, a closed-loop stress mitigation system using virtual reality multisensory stimulation and electrocardiography is designed and validated. A racing game was developed using Unity to induce controlled stress through competitive gameplay and a rapidly flashing trajectory. Twenty participants aged 24 ± 2 years were divided into two groups, comparing constant stimulation (Play 1) versus adaptive stimulation (Play 2), with order counterbalancing to eliminate learning effects. ECG signals were acquired with a Polar H10 chest strap and processed in real-time via a TCP/IP connection between Python and MATLAB.