Facial asymmetry is a complex and multifactorial clinical condition characterized by alterations in the skeletal, dental, functional, and soft tissue structures of the craniofacial region. Although a certain degree of asymmetry is part of the physiological variability of the individual, clinically relevant forms can have significant functional, aesthetic, and psychological consequences, affecting dental occlusion, masticatory function, phonation, and temporomandibular joint balance. Accurate diagnosis and proper treatment planning are therefore essential, particularly in cases of skeletal malocclusion associated with mandibular asymmetry, where orthodontic therapy alone may not be sufficient. Traditionally, facial asymmetry assessment has been based on two-dimensional methods, such as lateral and posteroanterior cephalometric analysis, which have intrinsic limitations related to the overlapping of anatomical structures, dependence on head orientation, and the inability to fully describe the three-dimensional nature of craniofacial deformities.