Geremia Lombardi
MAGNETOELECTRIC CORE-SHELL NANORODS FOR WIRELESS BRAIN STIMULATION: A COMPUTATIONAL MODELING STUDY.
Rel. Valentina Agostini, Emma Chiaramello. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2026
Abstract
Electrical stimulation of subcortical brain regions is an assessed method to achieve therapeutic neuronal modulation. Deep Brain Stimulation (DBS) grants to successfully treat neurological disorders such as Parkison Disease (PD), Essential Tremor (ET) and Dystonia, and has shown promising results for treating some neuropsychiatric disorders too. However, although effective, it remains an invasive treatment which requires surgical operation to be implanted and replaced in case of malfunctions. Non-invasive technologies, such as Transcranial Magnetic Stimulation (TMS), can wirelessly stimulate brain areas but their ability to reach deep brain structures is limited. To overcome this tradeoff between invasiveness and effectiveness, nanomaterials are gaining interest in literature, and, in particular, magnetoelectric nanoparticles represent a promising tool.
MENPs are two-phase nanoparticles consisting of a magnetostrictive core and a piezoelectric shell: under a low-amplitude applied magnetic field the magnetostrictive core stretches, inducing a change of electric potential by the piezoelectric shell
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