The development of eco-friendly synthesis routes for biocompatible nanoparticles is of growing interest in biomedical research. This thesis aims to explore the use of a non-thermal Atmospheric Pressure Plasma Jet array (APPJ array) device for the synthesis of pyrrole-based nanoparticles (NPs), investigating the influence of precursor flow rate, capillary-to-substrate distance, and voltage on: particle morphology, size distribution, and surface composition. Scanning electron microscopy analysis revealed that low flow rates, reduced distances, and moderate voltages lead to more uniform and spherical nanoparticle formation, while excessive values resulted in irregular aggregation of the NPs. FTIR and XPS demonstrated the presence of characteristic chemical groups of polypyrrole, such as C=C and N–H bonds, and suggested partial surface oxidation, likely due to interaction with reactive plasma species.