This thesis focuses on the implementation and application of ESA’s Thermo- Elastic Verification (TEV) software for the thermo-elastic analysis of satellite structures, with particular emphasis on the assessment of a space telescope’s performance parameters through uncertainty propagation. The objective of the study is to identify the design parameters that have the greatest impact on system performance and, consequently, to determine the most critical uncertainties affecting the overall satellite performance. A coupled thermal-structural approach is used to perform the thermo-elastic analysis. ESATAN-TMS, which calculates the temperature fields using the lumped parameter method, is first used to analyze the system’s thermal behavior. The pySinas tool is then used to map these temperature fields onto a structural finite element model created in NASTRAN.