The need to decarbonize industries and ensure energy security has also focused attention on hydrogen production using nuclear energy. In this context, this thesis aims to develop a comparative technical-economic analysis of the main nuclear technologies used in hydrogen production, with a focus on Small Modular Reactors with light water (SMR-LWR) and High Temperature Gas cooled Reactors (HTGR), which also include other subcategories such as VHTR and HTTR. The analysis is based on the identification of the main technical and economic parameters that influence the choice of reactor and hydrogen production process. The link between the thermodynamic characteristics of the reactor and the production paths useful for this new source is examined.