As the mobile communication landscape evolves to meet the demand for greater flexibility and efficiency, the shift from traditional monolithic architectures to a Disaggregated Radio Access Network has become a fundamental paradigm. Central to this evolution is the fronthaul interface, the link connecting the Distributed Unit to the Radio Unit, which must accommodate extreme bandwidths, ultra-low latencies, and diverse functional splits to support future use cases and different protocols. Carried out at OpenAirInterface (EURECOM), this thesis investigates the practical implementation of the 5G Open-fronthaul interface and explores 6G prototyping capabilities using Software Defined Radios. The work provides a comparative architectural analysis of two state-of-the-art platforms based on the RFSoC: the AMD Zynq UltraScale+ RFSoC DFE ZCU670 and the NI Ettus USRP X410, while also investigating the different fronthaul splits they employ.