The growing need for sustainable energy solutions necessitates the development of efficient and scalable technologies; in particular, techniques based on electrochemical conversion are now reaching industrial potential. This thesis is based on the scale-up and optimization of electrolyzer cell systems for efficient electrochemical conversion of carbon dioxide (CO2) into valuable chemicals, such as carbon monoxide (CO), a crucial intermediate in the production of synthetic fuels and chemicals. The research begins with a series of experimental investigations conducted to optimize the electrode materials, membranes, and operational parameters of a standard 5cm2 cell, in order to identify the best possible set-up, as well as key limitations and areas for improvement.