Supporting human wellbeing and natural regeneration through architectural and urban design choices should be the key driver in current projects. The regenerative design approach is about guiding architectural practice towards co-evolutionary systems, natural renewal and planetary health, as well as net-positive impacts across layers. This approach moves beyond sustainability. A holistic strategy that actively takes into account aspects of nature and biodiversity, emissions and circularity, society and cultures, co-design and continuous learning, urban context and mobility networks, doing this throughout the project life cycle. The thesis frames the question of how to transform existing buildings and sites into regenerative ecosystems that foster both human health and ecological restoration.