As human space exploration sets its goal to venture beyond low Earth orbit, toward long-duration missions to the Moon and Mars, the need for faster and more efficient Extravehicular activity (EVA) preparation becomes increasingly critical. Current prebreathe procedures used on the International Space Station (ISS) can last up to four hours, making them impractical and unsustainable for frequent or emergency EVAs in future extraterrestrial environments. In order to enable faster and safer operations, as well as to avoid decompression sickness, new prebreathe protocols need to be studied and developed. Therefore, this thesis investigates the physiological processes in the human body that lead to decompression sickness, and explores new options to mitigate the current long preparations.