Mandibular reconstruction is one of the most complex challenges in maxillofacial surgery, especially when bone segments must be replaced following trauma, tumors or other pathologies. The mandible’s intricate anatomy and its functional and aesthetic importance require high precision to restore it. Nowadays, patient-specific surgical guides are commonly employed to perform osteotomies, providing high precision, reliability and reproducibility. However, these guides are strictly dependent on the patient’s preoperative anatomy, which entails significant time and cost for their design and manufacturing, and makes them unusable in case of intraoperative anatomical changes. Moreover, they lack flexibility, as the cutting planes cannot be easily adjusted or reoriented during surgery.