Coronary artery disease (CAD) is a major global health problem, and clinical decision making is often based on anatomical severity of the stenosis and its functional relevance. In practice, however, anatomy and physiology do not always align, complicating the decision-making. In this thesis a centerline-based geometric characterization was developed, computing curvature, tortuosity, and local radius, from 3D reconstructions of diseased coronary segments to look beyond simple lumen narrowing. Reconstructions were performed for 28 patients and integrated with 25 additional cases from a companion thesis, for a total of 53 coronary reconstructions on which standardized geometric descriptors were computed. The aim of this work was to examine how anatomical and functional severity are related.