Atherosclerosis is an inflammatory vascular disease characterized by the development of lipid-rich plaques within the arterial wall. In coronary arteries, their growth leads to coronary artery disease (CAD) as a consequence of arterial lumen occlusion and eventually to myocardial infarction (MI) as most severe clinical event. Therefore, there is an urgent need of developing methods for CAD diagnosis and management. In clinical practice, the assessment of coronary lesion severity typically relies either on an anatomical evaluation, based on parameters associated with the local luminal narrowing, or on functional evaluation, based on fractional flow reserve (FFR), representing the flow reduction in the vessel due to the presence of a coronary lesion.