Nanotechnologies can enable new therapeutic frontiers, contributing to the creation of drug delivery smart system that can release the drug in response to specific stimuli such as temperature, ultrasound, magnetic electric fields, pH of the microenvironment. These devices make it possible to improve the spatio-temporal control of the administration of the therapeutic agent, reducing side effects and preserving healthy organs and tissues. In this context, piezoelectric materials, able to convert mechanical energy into electric energy, represent an emerging technology to develop innovative platforms to drive the release of drugs and are attracting more and more interest. Among them, Chitosan is a biodegradable piezoelectric natural polymer with low environmental impact, high biocompatibility and, thus, with a great potential to develop the next generation of controlled drug delivery systems.