Blood vessels perform essential biological functions in human body, including the transport of oxygen and nutrients and the removal of metabolic waste products. They regulate immune cell trafficking, maintain tissue homeostasis and contribute to processes such as angiogenesis and wound healing. Abnormalities in these structures are associated with different pathologies, including cardiovascular and neurodegenerative diseases, as well as cancer progression. To gain deeper insights into these mechanisms and to develop more physiologically relevant platforms for drug testing and regenerative medicine, it is crucial to integrate vascular-like networks into in vitro models. Nevertheless, engineering three-dimensional (3D) vessel-like architectures able to mimic the complexity of the native microenvironment remains highly challenging.