Human Health Risk Assessment (HHRA) is a fundamental step in the management of contaminated sites, linking site characterization with the design of soil and groundwater remediation. Given the complexity of exposure scenarios and the uncertainties in evaluating potential health effects, specialized software has become an essential tool for institutions and consultants. This thesis presents a critical comparison of two widely used programs, RBCA Tool Kit® and Risk-net®, both based on ASTM methodologies but designed for different contexts. The analysis is structured in three stages. First, the HHRA process is reviewed, highlighting hazard identification, exposure assessment, toxicity assessment, and risk characterization, with emphasis on the role of software in managing complex data.