Hydrothermal liquefaction is a promising technology for producing renewable fuels in Waste-to-Energy processes. Its great potential is being studied for commercial-scale biofuel production. This thesis investigates the technical and economic sustainability of valorising the Organic Fraction of Municipal Solid Waste (OFMSW) by coupling Anaerobic Digestion (AD) with Hydrothermal Liquefaction (HTL) of the digestate to produce different energy vectors (heat, electricity and biocrude). The simulation processes 60000 tons/y of OFMSW, according to data from public waste management plants in the Piedmont area, for a more plausible commercial evaluation. Mass and energy balances were performed for three different solids concentrations in the digestate after centrifugation: 8 wt.%, 17.5 wt.%, and 30 wt.%.