Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death in the world, right after lung cancer. Current conventional treatments do not guarantee complete effectiveness and present significant side effects. Nanomedicine has progressively gained ground in cancer therapy by enabling targeted and more effective treatment with reduced adverse effects due to its ability to interact directly at molecular level. Moreover, recent studies have revealed that tumor treatment with specific classes of nanoparticles (NPs), in combination with external acoustic waves stimulation, results in enhanced therapeutic efficacy. Based on these premises, this thesis project focuses on the development of biomimetic targeted NPs, capable of responding to an external stimulation in the form of shock waves (SW), for targeted treatment of CRC.