Diabetes Mellitus (DM) is a chronic disorder with global health impact, not only due to the mere pathology but also to its frequent association with various comorbidities and complications, such as cardiovascular diseases, obesity, neuropathy, and impaired wound healing. Given the increasing trend of overweight and obese diabetic patients, insulin resistance and the resulting biological cascades have gained significant research interest in recent years. Among the complications, foot ulcers are the most concerning type of chronic wounds in diabetic patients due to related comorbidities hindering healing and often leading to limb amputation. Despite the clinical relevance of DM, there is a remarkable lack of studies focused on diabetic skin and reliable easy-to-fabricate models to study the pathological phenomena and to test new treatments.