Ventral hernias are common complications in abdominal surgery, with a 10–20% incidence. A hernia occurs when viscera protrude through the abdominal wall, because of trauma or conditions increasing intra-abdominal pressure. These protrusions can cause chronic pain, impair daily movement, and, in severe cases, surgery is required to repair the defect. The most used repair method involves implantation of a mesh prosthesis to reinforce the abdominal wall and reduce the risk of hernia recurrence. One of the main limitations of traditional monolayer prosthesis is the risk of visceral adhesion, leading to bowel obstruction and infections. To mitigate this, bilayer meshes have been developed, combining a macroporous layer for abdominal wall reinforcement and a smooth layer to prevent organ adhesion.