In the wide spectrum of cardiovascular diseases (CVD), the ascending thoracic aortic aneurysm (ATAA) is a critical condition, due to its silent progression and the severe complications, such as aortic dissection, rupture, or sudden death. Current clinical guidelines for surgical intervention - typically based on maximum aortic diameter criterion - are not always reliable predictors of individual patient risk, as they do not account for biomechanical and hemodynamic factors that drive aneurysm progression. Although widely employed to investigate blood flow patterns and wall shear stress distribution in the aorta, Computational Fluid Dynamics (CFD) generally assumes a rigid vessel wall. In contrast, Fluid-Structure Interaction (FSI) simulations account for the mechanical interplay between flow-induced forces and wall deformation, thus providing a more realistic representation of the biomechanical environment.