Implantable drug delivery systems are transforming personalized medicine by enabling localized and controlled therapeutic administration. However, achieving precise, real-time modulation of drug release in response to dynamic physiological conditions remains a significant challenge. Here, we present the development of an implantable nanofluidic micromotor-driven device, capable of modulating in vitro drug release via a temperature-responsive closed-loop system. The device exploits electro-mechanical actuation generated by a micromotor to open and close an integrated channel, enabling controlled drug release. This function is enhanced by a nanofluidic membrane that further regulates molecular transport. The closed-loop system is implemented in a custom-built polystyrene chamber, designed to simulate in vivo thermal conditions.