Wearable epidermal devices are emerging as powerful tools for continuous, non-invasive health monitoring via sweat biomarker analysis. To enable on-demand sweat extraction when physiological sweat is absent, these systems must deliver specific drugs transdermally to stimulate secretion. Iontophoresis, which uses a mild electric current to transport charged drugs through the skin, is a promising solution. However, integrating drug reservoirs into wearable systems remains a challenge. Conventional hydrogels, used for drug delivery, suffer from fabrication complexity and rapid water loss, limiting shelf-life. This thesis addresses some of these issues by using agarose-based hydrogel modified with glycerol for improved long-term water retention. A scalable fabrication method was developed to integrate the agarose/glycerol hydrogel into a wearable iontophoretic device for sweat stimulation and collection.