Soft Tissue Sarcoma (STS) constitute an heterogenous group of rare malignancies with more than 70 subtypes. Due to the high variability among the different histotypes, STS represent a challenging field in terms of diagnosis and therapy. Over the last 50 years the therapeutic approaches have remained almost unchanged, and the outcomes are still limited. This thesis project will focus on the localized disease, where the cornerstone treatment is surgery. However, it is not always possible to achieve negative surgical margins and minimizing functional impairment, particularly when dealing with large masses located in hard to access areas, such as the retroperitoneum. The aim of the project is to overcome these limits through the development of a polymeric nanofibrous mesh engineered with therapeutic liposomes encapsulated into a Gel-MA hydrogel.