Exposure to Cadmium and Chromium(VI) through multiple sources and routes.

In a context of growing attention towards chemical risk management, this thesis is part of the European PARC project (Partnership for the Assessment of Risks from Chemicals), focusing on the assessment of aggregate exposure to Cadmium (Cd) and Hexavalent Chromium (Cr(VI)), known for their toxic and carcinogenic effects. The activity mainly concerned the analysis of occupational exposure through the processing of data provided by SUVA (Swiss National Accident Insurance Fund), combining bio-monitoring and exposure modeling approaches. Specific scenarios were defined for homogeneous exposure groups (HEG), on which predictive modeling of external doses was applied. The analysis showed significant differences between occupational groups, gender, and age ranges, as well as a general trend of decreasing concentrations of Cd and Cr(VI) over time. The results obtained will be converted using PBPK models and subsequently aggregated to improve the definition of chemical risk, and finally compared with bio-monitoring data.