Peripheral artery disease (PAD) is a condition primarily affecting the arteries of the legs. It is most commonly caused by atherosclerosis, which leads to partial or complete obstruction of blood vessels. This reduced blood flow results in insufficient oxygen supply to downstream tissues, often causing leg muscle pain and, in severe cases, leading to gangrene and potential amputation of the lower limbs. The morphological characteristics and stability of atherosclerotic plaques vary throughout the vascular tree. The distal superficial femoral artery (SFA) at the adductor hiatus (AH) and the popliteal artery (PA) behind the knee are common sites of atherosclerosis. These regions undergo significant deformation during limb flexion, promoting vascular injury, cellular proliferation, and disease progression, and resulting in tortuous segments with complex flow dynamics.