Marta Di Ridolfi
Latent Dynamics Neural Network models of cardiac electrophysiology in a patient-specific left atrium.
Rel. Luigi Preziosi, Stefano Pagani, Luca Dede', Alfio Quarteroni. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Matematica, 2025
Abstract
Simulating left atrial electrophysiology is crucial for advancing the diagnosis and treatment of heart diseases. The traditional modeling and simulation approach involves coupling a monodomain equation, which describes the propagation of the transmembrane potential throughout the left atrium, with the Courtemanche-Ramirez-Nattel model, which characterizes atrial electrophysiology at the cellular scale. High-fidelity discretizations, utilizing methods such as the Galerkin Finite Element method and a Backward Difference Formula scheme, demand substantial computational resources, particularly when multiple solutions are needed for varying key parameters of the problem. This makes the full-order model not applicable to clinical scenarios that require real-time and multiple simulations. To reach an efficient solution of the parametric problem, this thesis employs a data-driven approach, called Latent Dynamics Network (LDNet).
By leveraging a neural ODE, the system’s evolution is mapped into a low-dimensional space using a few latent variables
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