The Mississippi River Delta (MRD) is a complex and dynamic eco-region that is essential for biodiversity and coastal protection. Yet, the MRD is increasingly vulnerable to climate change, salt intrusion, and extreme drought events, which threaten its ecological stability. This study developed and applied an eco-hydrological model to analyze the combined effects of these stressors on wetland vegetation. Specifically, it focused on the increase in salinity during the 2022 drought and its negative impact on plant productivity. The original eco-hydrological model, Photo3 (Hartzell et al. 2018; publicly available at: https://github.com/samhartz/Photo3) was modified to account for soil saturation and the effects of salinity on plant transpiration.