Giovanni Errante
Design and fabrication of a wearable device for early stage detection of Parkinson's disease.
Rel. Matteo Cocuzza, Simone Luigi Marasso, Alberto Ballesio. Politecnico di Torino, Corso di laurea magistrale in Nanotechnologies For Icts (Nanotecnologie Per Le Ict), 2024
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Abstract
In recent years, the demand for small electronic sensors able to monitor biological signals is increasing. This is due to the large possibilities offered by these devices, like the ability to sense small variations in the concentration of an analyte, record it in time and then visualize a change that could be indicative of a pathological state. The goal of this thesis is an early stage detection of Parkinson’s disease, one of the most widespread neurological disorders in the world. Since there is not currently a screening method, there is a high request for a standardized, repeatable and robust test able to sense if the patient shows early signs of the disease.
This can be achieved through the measurement of the alpha-synuclein protein level in the skin, since when overproduced, it constitutes a biomarker of the disease
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