Alessia Tatasciore
Depth-dependent biaxial biomechanical characterization of the corneal stroma: an experimental and numerical study.
Rel. Andrea Mura, Luigi Mazza. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
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Abstract
The World Health Organization reports that over 2.2 billion people worldwide are affected by visual impairments, most of which occur in low- and middle-income countries. While vision problems are not life-threatening, they significantly impact the quality of life. Common refractive errors, such as myopia, hyperopia, presbyopia, and astigmatism, can be corrected using laser refractive surgery, which reshapes the patient’s cornea. However, challenges remain, including the risk of suboptimal postoperative results and ectasia, partly due to insufficient personalization of the cornea's mechanical properties in surgical planning. The cornea provides approximately two-thirds of the eye's refractive power, so even minor alterations in its shape can significantly affect vision.
As the cornea maintains a constant mechanical equilibrium with intraocular pressure, small variations in its stiffness can disrupt this balance, altering its shape and thus affecting the patient’s vision
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